Title | When IL-17 gets on your nerves. |
Publication Type | Journal Article |
Year of Publication | 2023 |
Authors | Iliev ID, Lin W-Y, Gaffen SL |
Journal | Cell |
Volume | 186 |
Issue | 3 |
Pagination | 466-468 |
Date Published | 2023 Feb 02 |
ISSN | 1097-4172 |
Keywords | Animals, Axons, Central Nervous System, Interleukin-17, Nerve Regeneration, Peripheral Nerves, Peripheral Nervous System, Signal Transduction |
Abstract | Microbiota-induced IL-17 production mediates CNS processes and animal behavior. However, its role on the peripheral nervous system (PNS) remains largely unknown. Enamorado et al. demonstrate that commensal-specific Th17 cells are recalled following tissue injury to support local nerve regeneration, a process orchestrated by IL-17 signaling on peripheral neurons. |
DOI | 10.1016/j.cell.2022.12.048 |
Alternate Journal | Cell |
PubMed ID | 36736299 |
Grant List | R01 AI163007 / AI / NIAID NIH HHS / United States R01 DK113136 / DK / NIDDK NIH HHS / United States R01 DK121977 / DK / NIDDK NIH HHS / United States |