| Title | When IL-17 gets on your nerves. |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Iliev ID, Lin W-Y, Gaffen SL |
| Journal | Cell |
| Volume | 186 |
| Issue | 3 |
| Pagination | 466-468 |
| Date Published | 2023 Feb 02 |
| ISSN | 1097-4172 |
| Keywords | Animals, Axons, Central Nervous System, Interleukin-17, Nerve Regeneration, Peripheral Nerves, Peripheral Nervous System, Signal Transduction |
| Abstract | Microbiota-induced IL-17 production mediates CNS processes and animal behavior. However, its role on the peripheral nervous system (PNS) remains largely unknown. Enamorado et al. demonstrate that commensal-specific Th17 cells are recalled following tissue injury to support local nerve regeneration, a process orchestrated by IL-17 signaling on peripheral neurons. |
| DOI | 10.1016/j.cell.2022.12.048 |
| Alternate Journal | Cell |
| PubMed ID | 36736299 |
| Grant List | R01 AI163007 / AI / NIAID NIH HHS / United States R01 DK113136 / DK / NIDDK NIH HHS / United States R01 DK121977 / DK / NIDDK NIH HHS / United States |