Breaching self-tolerance by targeting the gatekeeper.

TitleBreaching self-tolerance by targeting the gatekeeper.
Publication TypeJournal Article
Year of Publication2021
AuthorsWan Z, Pascual V
JournalJ Exp Med
Volume218
Issue5
Date Published2021 05 03
ISSN1540-9538
KeywordsAnimals, Cell-Derived Microparticles, DNA, Endodeoxyribonucleases, Humans, Mice
Abstract

Loss-of-function mutations in DNaseL13, the enzyme that restricts the amount of microparticle-associated DNA, cause SLE in humans and mice. In this issue of JEM, Hartl et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201138) uncover a reduction in plasma DNASE1L3 enzymatic activity due to the presence of autoantibodies in patients with nonfamilial SLE.

DOI10.1084/jem.20210322
Alternate JournalJ Exp Med
PubMed ID33847707
PubMed Central IDPMC8047933

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