Title | Breaching self-tolerance by targeting the gatekeeper. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Wan Z, Pascual V |
Journal | J Exp Med |
Volume | 218 |
Issue | 5 |
Date Published | 2021 05 03 |
ISSN | 1540-9538 |
Keywords | Animals, Cell-Derived Microparticles, DNA, Endodeoxyribonucleases, Humans, Mice |
Abstract | Loss-of-function mutations in DNaseL13, the enzyme that restricts the amount of microparticle-associated DNA, cause SLE in humans and mice. In this issue of JEM, Hartl et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201138) uncover a reduction in plasma DNASE1L3 enzymatic activity due to the presence of autoantibodies in patients with nonfamilial SLE. |
DOI | 10.1084/jem.20210322 |
Alternate Journal | J Exp Med |
PubMed ID | 33847707 |
PubMed Central ID | PMC8047933 |